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               Cultivation/production methods:
               Saccharomyces cerevisiae production in Colombia is mainly carried out by batch and continuous cultivation methods. The choice of method
               depends on factors such as the scale of production, the quality required and the resources available.

               YEAST in Colombia:                                                                                                                       Species, ingredients and companies

               Yeast products have traditionally been used in the food industry, however, it has given way to research and development to generate innovations
               in cosmetic applications and the health industry.


               Supply of yeast-derived ingredients from Colombia

                     Ingredient    YEAST BETAGLUCAN                                           YEAST EXTRACT + COFFEA CHERRY

               Bioactive ingredients  Category  BIOACTIVE INGREDIENT
                     Company that   COMPAÑÍA NACIONAL DE LEVADURAS, LEVAPAN                  COMPAÑÍA NACIONAL DE LEVADURAS, LEVAPAN
                     produces it
                     INCI name     Yeast Beta- Glucan Biosuspension                          Coffee cherry and Yeast extract bioemulsion
                     Sector        Cosmetic                                                  Cosmetic
                                     Homogeneous viscous liquid.                               Homogeneous viscous liquid.
                     Presentation    Innoskin Anti-Age: yeast beta-glucan biosuspension.       Innoskin Brightening: bioemulsion of coffee, cherry and yeast extract.
                                     Packaged in presentations of 1, 5 and 10 kilograms.       Packaged in presentations of 1, 5 and 10 kilograms.
                                     Natural, self-preserved and dermatologically tested cosmetic active     Natural cosmetic ingredient that inhibits the enzyme tyrosinase,
                                    ingredient of purified beta-glucan obtained from Biolev by Levapan® yeast   which causes skin hyperpigmentation, up to 80% at 0.5%
                     Technical      with moisturizing, nourishing and regenerating properties for the skin.    concentration and 100% inhibition at 2% concentration.
                     information     Density 1.10g/ml.                                         Density 1.10- 1.25 g/ml.
                                     Ph 4.8-6.8.                                               Ph 3.8-6.0.
                                     Shelf life: 24 months.                                    Shelf life: 24 months.
                                     It has a technical data sheet, safety data sheet, and recommendations      It has a technical data sheet, safety data sheet and recommendations
                                    for use.                                                  for use.
                     Quality and     Safety studies in Europe under OECD 439: In Vitro Skin Irritation:     Safety studies in Europe under OECD 439: In Vitro Skin Irritation:
                     safety         Reconstructed Human Epidermis Test Method.                Reconstructed Human Epidermis Test Method.
                                     In vivo safety study Patch Test.                          In vivo safety study PATCH Test.
                                     Leaping Bunny (animal cruelty free).                      Leaping Bunny (animal cruelty free).
                     Certifications/
                     seals           ISO 10993 standard for testing biomaterials and medical devices.     ISO 10993 standard for testing biomaterials and medical devices.

                     Regulatory      Complies with European Union cosmetic regulations.        Complies with European Union cosmetic regulations.
                     compliance
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